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Hodgkin's Lymphoma

Hodgkin's Lymphoma This is progressive, painless enlargement of lymphoid tissues throughout the body. EB virus involvement is thought to be one of the aetiologies. Pathological classification Lymphocyte predominant Nodular sclerosis Mixed cellularity Lymphocyte depleted Characteristically, cells with mirror image nuclei (REED-STERNBERG CELLS) are seen. Clinical features Patient present with enlarged, painless lymph nodes, alcohol induced pain pain over the enlarged nodes, and features due to the mass effect of the node. 25% have constitutional symptoms like fever, weight loss, night sweats and pruritus. Hepatosplenomegaly may also be present. Investigations Lymph node biopsy  Bone marrow biopsy Liver biopsy Lymphopenia indicates bad prognosis. Moderate eosinophilia may occur in 10 to 15% of the patients. Clinical staging (Ann-Arbor Classification) Stage 1 Involvement of a single lymph node region (1) or extra-lymphatic site (E) Stage 2 Involvement of two or more lymph node regions ...

HYPERTENSION (High Blood Pressure)

HYPERTENSION (High Blood Pressure) The British Hypertension Society classification, defines mild hypertension as existing when the BP is above 140/90 mmHg.  The Cardiovascular risks associated with high BP depend on the combination of risk factors in an individual, such as age, gender, weight, physical activity, smoking, family history, serum cholesterol, diabetes mellitus and pre-existing vascular disease. Classification of Hypertension Causes of Hypertension Alcohol  Obesity  Pregnancy RENAL DISEASE Glomerulonephritis Renal vascular disease Polycystic kidney disease ENDOCRINE DISEASE Pheochromocytoma Cushing's syndrome Primary hyperaldosteronism (Conn's syndrome) Thyrotoxicosis Acromegaly  Primary hypothyroidism Liddle's syndrome Congenital adrenal hyperplasia COARCTATION OF THE AORTA DRUGS Steroids : Anabolic steroids, corticosteroid, oral contraceptive pills. Cyclosporine Beta receptor agonists Sympathomimetics (Cold remedies/ Nasal drops) NSAIDs Causes of isolat...

Rheumatoid arthritis (RA)

  Rheumatoid arthritis  is a chronic inflammatory, destructive and deforming symmetrical polyarthritis associated with systemic involvement. The individuals with HLA-D4 and HLA-DR4 are more prone to RA. It starts when your immune system, which is supposed to protect you, goes awry and begins to attack your body’s own tissues. It causes  inflammation   in the lining of your joints (the synovium). As a result, your joints may get red, warm, swollen, and painful. Symptoms of Rheumatoid Arthritis Joint pain and swelling Stiffness, especially in the morning or after you sit for a long time Fatigue Who Gets Rheumatoid Arthritis? Anyone can get RA. It affects about 1% of Americans. The disease is 2 to 3 times more common in women than in men, but men tend to have more severe symptoms. It usually starts in middle age. But young children and the elderly also can get it. Pathogenesis Synovitis (synovial cell hyperplasia, hypertrophy with CD4 lymphocytic infiltration and synovi...